Dry eye is a common, multifactorial disease currently diagnosed by a combination of
symptoms and signs. Its epidemiology and clinical presentation have many similarities with …

Results Several reported cases and a small number of randomized trials were published in
recent years, describing different methods of DRG stimulation and neuromodulation with …

Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain
processing. They are often studied in vitro as dissociated cell cultures with the assumption …

Neuropathic pain is a major, inadequately treated challenge for people with spinal cord
injury (SCI). While SCI pain mechanisms are often assumed to be in the CNS, rodent studies …

Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but
rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain …

Spinal cord injury (SCI) causes maladaptive changes to nociceptive synaptic circuits within
the injured spinal cord. Changes also occur at remote regions including the brain stem …

Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating
nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that …

There is a pressing need for understanding of factors that confer resilience to pain. Gain-of-
function mutations in sodium channel Nav1. 7 produce hyperexcitability of dorsal root …

Native M-current is a low-threshold, slowly activating potassium current that exerts an
inhibitory control over neuronal excitability. The M-channel is primarily co-assembled by …

Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …