Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Pituitary tumors account for about 15% of primary intracranial neoplasms. Proliferation of
pituitary cells, which secrete hormones, may result in a spectrum of endocrine symptoms …

The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure
and thereby regulate the transcription of several genes by either enhancing or suppressing …

Cellular senescence is a stable state of proliferative arrest that provides a barrier to
malignant transformation and contributes to the antitumor activity of certain chemotherapies …

Non-coding RNAs represent a majority of the human transcriptome. However, less is known
about the functions and regulatory mechanisms of most non-coding species. Moreover, little …

Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN)
participate in many of the same nuclear processes, each family plays its own unique role in …

The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous
nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the …

The 'high mobility group'HMGA protein family consists of four members: HMGA1a, HMGA1b
and HMGA1c, which result from translation of alternative spliced forms of one gene and …

Introduction• Gene structure and regulation• Target molecules• Role in development• Role in
cancer• Other biological functions• Summary and perspectives The discovery of microRNAs …

Spliced X-box–binding protein 1 (XBP1s) is an essential transcription factor downstream of
interleukin-15 (IL-15) and AKT signaling, which controls cell survival and effector functions of …