Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Degradation of Gram-positive bacterial cell wall peptidoglycan in macrophage and dendritic
cell phagosomes leads to activation of the NLRP3 inflammasome, a cytosolic complex that …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic
cells′ life. Up to the 1990s of the past century, ROS have been solely considered as toxic …

Autophagy is required in diverse paradigms of lifespan extension, leading to the prevailing
notion that autophagy is beneficial for longevity. However, why autophagy is harmful in …

Permeabilization of the mitochondrial membranes is a crucial step in apoptosis and
necrosis. This phenomenon allows the release of mitochondrial death factors, which trigger …