The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis
Z Sun, Q Jiang, J Li, J Guo - Signal transduction and targeted therapy, 2020 - nature.com
Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and
functions mainly involve in regulating energy response-related physiological processes …
functions mainly involve in regulating energy response-related physiological processes …
Salt-inducible kinases: physiology, regulation by cAMP, and therapeutic potential
MN Wein, M Foretz, DE Fisher, RJ Xavier… - Trends in Endocrinology …, 2018 - cell.com
Salt-inducible kinases (SIKs) represent a subfamily of AMP-activated protein kinase (AMPK)
family kinases. Initially named because SIK1 (the founding member of this kinase family) …
family kinases. Initially named because SIK1 (the founding member of this kinase family) …
A menin-MLL inhibitor induces specific chromatin changes and eradicates disease in models of MLL-rearranged leukemia
AV Krivtsov, K Evans, JY Gadrey, BK Eschle, C Hatton… - Cancer cell, 2019 - cell.com
Inhibition of the Menin (MEN1) and MLL (MLL1, KMT2A) interaction is a potential therapeutic
strategy for MLL-rearranged (MLL-r) leukemia. Structure-based design yielded the potent …
strategy for MLL-rearranged (MLL-r) leukemia. Structure-based design yielded the potent …
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
MM Dzama, M Steiner, J Rausch… - Blood, The Journal …, 2020 - ashpublications.org
The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a
potential opportunity for treatment of NPM1-mutant (NPM1 mut) and MLL-rearranged (MLL-r) …
potential opportunity for treatment of NPM1-mutant (NPM1 mut) and MLL-rearranged (MLL-r) …
LKB1, salt-inducible kinases, and MEF2C are linked dependencies in acute myeloid leukemia
The lineage-specific transcription factor (TF) MEF2C is often deregulated in leukemia.
However, strategies to target this TF have yet to be identified. Here, we used a domain …
However, strategies to target this TF have yet to be identified. Here, we used a domain …
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia
Acute myeloid leukemias (AML) are characterized by mutations of tumor suppressor and
oncogenes, involving distinct genes in adults and children. While certain mutations have …
oncogenes, involving distinct genes in adults and children. While certain mutations have …
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia
Acute myeloid leukemia (AML) remains difficult to treat and requires new therapeutic
approaches. Potent inhibitors of the chromatin-associated protein MENIN have recently …
approaches. Potent inhibitors of the chromatin-associated protein MENIN have recently …
Current methods of post-translational modification analysis and their applications in blood cancers
Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells
Understanding clonal evolution and cancer development requires experimental approaches
for characterizing the consequences of somatic mutations on gene regulation. However, no …
for characterizing the consequences of somatic mutations on gene regulation. However, no …
Progress on the roles of MEF2C in neuropsychiatric diseases
Z Zhang, Y Zhao - Molecular brain, 2022 - Springer
Abstract Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-
BOX family, is involved in embryonic brain development, neuronal formation and …
BOX family, is involved in embryonic brain development, neuronal formation and …