NAD+ is a fundamental molecule in metabolism and redox signaling. In diabetes and its
complications, the balance between NADH and NAD+ can be severely perturbed. On one …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

One of the highlights of postmitotic aging is the intracellular accumulation of highly oxidized
and cross‐linked proteins, known as lipofuscin. Lipofuscin is insoluble and not degradable …

Active autophagy coupled with rapid mitochondrial fusion and fission constitutes an
important mitochondrial quality control mechanism and is critical to cellular health. In our …

The role of mitochondrial dysfunction and oxidative stress has been extensively
characterized in the aetiology of sarcopenia (aging-associated loss of muscle mass) and …

The molecular mechanisms underlying thiol-based redox control are poorly defined.
Disulfide bonds between Cys residues are commonly thought to confer extra rigidity and …

Disulfide bonds play a key role in stabilizing protein structures, with disruption strongly
associated with loss of protein function and activity. Previous data have suggested that …

Acute bouts of aerobic and anaerobic exercise can induce a state of oxidative stress, as
indicated by an increase in oxidized molecules in a variety of tissues and body fluids. The …

The GSH: GSSG ratio, which is the primary determinant of the cellular redox state, becomes
progressively more pro-oxidizing during the aging process due to an elevation in the GSSG …

The tripeptide glutathione (GSH) and its oxidized form glutathione disulfide (GSSG)
constitute a key redox couple in cells. In particular, they partner protein thiols in reversible …