[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

DP Ramji, TS Davies - Cytokine & growth factor reviews, 2015 - Elsevier
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy

JE McLaren, DR Michael, TG Ashlin, DP Ramji - Progress in lipid research, 2011 - Elsevier
Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways

A Roy, M Srivastava, U Saqib, D Liu, SM Faisal… - International …, 2016 - Elsevier
Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …

Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets

JWE Moss, DP Ramji - Future medicinal chemistry, 2016 - Future Science
Atherosclerosis, the primary cause of cardiovascular disease (CVD), is a chronic
inflammatory disorder in the walls of medium and large arteries. CVD is currently …

Atherosclerosis and interferon-γ: new insights and therapeutic targets

I Voloshyna, MJ Littlefield, AB Reiss - Trends in cardiovascular medicine, 2014 - Elsevier
Atherosclerosis is considered to be a chronic inflammatory disease of the arterial wall.
Atherogenesis is accompanied by local production and release of inflammatory mediators …

[HTML][HTML] Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor

TWH Pols, T Puchner, HI Korkmaz, M Vos… - PLoS …, 2017 - journals.plos.org
Bile acids are established signaling molecules next to their role in the intestinal
emulsification and uptake of lipids. We here aimed to identify a potential interaction between …

Exercise mimetics and JAK inhibition attenuate IFN-γ–induced wasting in engineered human skeletal muscle

Z Chen, B Li, RZ Zhan, L Rao, N Bursac - Science Advances, 2021 - science.org
Chronic inflammatory diseases often lead to muscle wasting and contractile deficit. While
exercise can have anti-inflammatory effects, the underlying mechanisms remain unclear …

[HTML][HTML] The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis

ML Buckley, DP Ramji - Biochimica et Biophysica Acta (BBA)-Molecular …, 2015 - Elsevier
Atherosclerosis, the underlying cause of myocardial infarction and thrombotic
cerebrovascular events, is responsible for the majority of deaths in westernized societies …

[HTML][HTML] Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in …

W Sheng, Y Zong, A Mohammad, D Ajit, J Cui… - Journal of …, 2011 - Springer
Background Activation of glial cells, including astrocytes and microglia, has been implicated
in the inflammatory responses underlying brain injury and neurodegenerative diseases …

Proteomic Quantification and Site-Mapping of S-Nitrosylated Proteins Using Isobaric iodoTMT Reagents

Z Qu, F Meng, RD Bomgarden, RI Viner… - Journal of proteome …, 2014 - ACS Publications
S-Nitrosylation is a redox-based protein post-translational modification in response to nitric
oxide signaling and is involved in a wide range of biological processes. Detection and …