Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
Mitochondrial heterogeneity and homeostasis through the lens of a neuron
G Pekkurnaz, X Wang - Nature metabolism, 2022 - nature.com
Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …
properties. The dynamic network of mitochondria undergoes structural and functional …
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control
T König, H Nolte, MJ Aaltonen, T Tatsuta, M Krols… - Nature cell …, 2021 - nature.com
Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes—
for example, mitochondrial quality control—and are linked to various neurodegenerative …
for example, mitochondrial quality control—and are linked to various neurodegenerative …
Nuclear-mitochondrial interactions
BR Walker, CT Moraes - Biomolecules, 2022 - mdpi.com
Mitochondria, the cell's major energy producers, also act as signaling hubs, interacting with
other organelles both directly and indirectly. Despite having its own circular genome, the …
other organelles both directly and indirectly. Despite having its own circular genome, the …
Microtubule acetylation dyshomeostasis in Parkinson's disease
P Naren, KS Samim, KP Tryphena, LK Vora… - Translational …, 2023 - Springer
The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …
Mitochondrial protein dysfunction in pathogenesis of neurological diseases
L Wang, Z Yang, X He, S Pu, C Yang, Q Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …
Shared structural features of Miro binding control mitochondrial homeostasis
C Covill-Cooke, B Kwizera, G López-Doménech… - The EMBO …, 2024 - embopress.org
Miro proteins are universally conserved mitochondrial calcium-binding GTPases that
regulate a multitude of mitochondrial processes, including transport, clearance, and lipid …
regulate a multitude of mitochondrial processes, including transport, clearance, and lipid …
The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis
J Liu, Z Huang, S Yin, X Zhou, Y Jiang… - Science of the Total …, 2023 - Elsevier
Given their increasing industrial and biomedical applications, silver nanoparticles (AgNPs)
have become widely present in the environment. However, to date, studies on their potential …
have become widely present in the environment. However, to date, studies on their potential …
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia
Cerebral ischemia induces massive mitochondrial damage, leading to neuronal death. The
elimination of damaged mitochondria via mitophagy is critical for neuroprotection. Here we …
elimination of damaged mitochondria via mitophagy is critical for neuroprotection. Here we …
Mitophagy and traumatic brain injury: regulatory mechanisms and therapeutic potentials
Y Luan, L Jiang, Y Luan, Y Xie… - … Medicine and Cellular …, 2023 - Wiley Online Library
Traumatic brain injury (TBI), a kind of external trauma‐induced brain function alteration, has
posed a financial burden on the public health system. TBI pathogenesis involves a …
posed a financial burden on the public health system. TBI pathogenesis involves a …