Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondrial heterogeneity and homeostasis through the lens of a neuron

G Pekkurnaz, X Wang - Nature metabolism, 2022 - nature.com
Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

T König, H Nolte, MJ Aaltonen, T Tatsuta, M Krols… - Nature cell …, 2021 - nature.com
Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes—
for example, mitochondrial quality control—and are linked to various neurodegenerative …

Nuclear-mitochondrial interactions

BR Walker, CT Moraes - Biomolecules, 2022 - mdpi.com
Mitochondria, the cell's major energy producers, also act as signaling hubs, interacting with
other organelles both directly and indirectly. Despite having its own circular genome, the …

Microtubule acetylation dyshomeostasis in Parkinson's disease

P Naren, KS Samim, KP Tryphena, LK Vora… - Translational …, 2023 - Springer
The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Mitochondrial protein dysfunction in pathogenesis of neurological diseases

L Wang, Z Yang, X He, S Pu, C Yang, Q Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …

Shared structural features of Miro binding control mitochondrial homeostasis

C Covill-Cooke, B Kwizera, G López-Doménech… - The EMBO …, 2024 - embopress.org
Miro proteins are universally conserved mitochondrial calcium-binding GTPases that
regulate a multitude of mitochondrial processes, including transport, clearance, and lipid …

The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis

J Liu, Z Huang, S Yin, X Zhou, Y Jiang… - Science of the Total …, 2023 - Elsevier
Given their increasing industrial and biomedical applications, silver nanoparticles (AgNPs)
have become widely present in the environment. However, to date, studies on their potential …

PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia

I Hwang, BS Kim, HY Lee, SW Cho, SE Lee, JY Ahn - Autophagy, 2024 - Taylor & Francis
Cerebral ischemia induces massive mitochondrial damage, leading to neuronal death. The
elimination of damaged mitochondria via mitophagy is critical for neuroprotection. Here we …

Mitophagy and traumatic brain injury: regulatory mechanisms and therapeutic potentials

Y Luan, L Jiang, Y Luan, Y Xie… - … Medicine and Cellular …, 2023 - Wiley Online Library
Traumatic brain injury (TBI), a kind of external trauma‐induced brain function alteration, has
posed a financial burden on the public health system. TBI pathogenesis involves a …