The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

Growth factors are important morphogenetic proteins that instruct cell behavior and guide
tissue repair and renewal. Although their therapeutic potential holds great promise in …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which
relatively conserved intracellular kinase domains are coupled to divergent extracellular …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …

Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …

The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …

The internalization of various cargo proteins and lipids from the mammalian cell surface
occurs through the clathrin and lipid-raft endocytic pathways. Protein–lipid and protein …