DNA methylation and histone modifications associated with antipsychotic treatment: A systematic review
Antipsychotic medications are essential when treating schizophrenia spectrum and other
psychotic disorders, but the efficacy and tolerability of these medications vary from person to …
psychotic disorders, but the efficacy and tolerability of these medications vary from person to …
Schizophrenia is associated with altered DNA methylation variance
Varying combinations of genetic and environmental risk factors are thought to underpin
phenotypic heterogeneity between individuals in psychiatric conditions such as …
phenotypic heterogeneity between individuals in psychiatric conditions such as …
Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease
C Xu, X Fu, H Qin, K Yao - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
DNA methylation plays a crucial role in development, aging, degeneration of various tissues
and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation …
and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation …
Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans
The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been
inconsistent, with few studies investigating biological outcomes in humans. We profiled …
inconsistent, with few studies investigating biological outcomes in humans. We profiled …
[HTML][HTML] Inflammation Proteomic Profiling of Psychosis in Young Adults: findings from the ALSPAC birth cohort
Psychotic disorder is associated with altered levels of various inflammatory markers in
blood, but existing studies have typically focused on a few selected biomarkers, have not …
blood, but existing studies have typically focused on a few selected biomarkers, have not …
New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment
Schizophrenia (SZ) is a complex neuropsychiatric disorder associated with severe cognitive
dysfunction. Although research has mainly focused on forebrain abnormalities, emerging …
dysfunction. Although research has mainly focused on forebrain abnormalities, emerging …
Intergenerational transmission of complex traits and the offspring methylome
The genetic makeup of parents can directly or indirectly affect their offspring phenome
through genetic transmission or via the environment that is influenced by parental heritable …
through genetic transmission or via the environment that is influenced by parental heritable …
Epigenetic signatures in children and adolescents at familial high risk: linking early-life environmental exposures to psychopathology
AG Segura, I Martinez-Serrano, E de la Serna… - 2024 - researchsquare.com
Background This study investigates the relationship between environmental risk factors and
severe mental disorders using genome-wide methylation data. Methylation profile scores …
severe mental disorders using genome-wide methylation data. Methylation profile scores …
Investigating Clozapine-Induced Myocarditis in Stem Cell-Derived Cardiomyocytes from Treatment-Resistant Schizophrenia Patients: A Pharmacoepigenomic …
D Ferri Marques - 2024 - prism.ucalgary.ca
Clozapine, an antipsychotic with proven efficacy for treatment-resistant schizophrenia, is
often underutilized due to the risk of severe side effects such as myocarditis (cardiac …
often underutilized due to the risk of severe side effects such as myocarditis (cardiac …