Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins,
and other molecules, and has been used in many research fields because of its beneficial …

Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …

Noncovalent interactions between cells and environmental cues have been recognized as
fundamental physiological interactions that regulate cell behavior. However, the effects of …

In the search for fundamentally new, active, stable, and readily synthetically accessible
cycloalkynes as strain-promoted azide–alkyne cycloaddition (SPAAC) reagents for …

Background Exosomes are nano-sized vesicles derived from the fusion of multivesicular
bodies with the surrounding plasma membrane. Exosomes have various diagnostic and …

Chimeric antigen receptor T (CAR-T) cell therapy has faced a series of challenges and has
shown very little efficacy in solid tumors to date. Although genetically engineered …

Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved
in a multitude of biological processes and aberrant sialic acid expression is associated with …

The modulation of inflammatory responses plays an important role in the pathobiology of
cardiac failure. In a natural healing process, the ingestion of apoptotic cells and their …

Background The inflammatory tumor microenvironment (TME) is formed by various immune
cells, being closely associated with tumorigenesis. Especially, the interaction between tumor …

Circulating tumor cells (CTCs) are the “seeds” for malignant tumor metastasis, and they
serve as an ideal target for minimally invasive tumor diagnosis. Abnormal glycolysis in tumor …