Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …

Background Atypical teratoid/rhabdoid tumors (ATRTs) are known to exhibit molecular and
clinical heterogeneity even though SMARCB1 inactivation is the sole recurrent genetic event …

Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly
aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often …

Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …

One of the leading causes of death worldwide, in both men and women, is cancer. Despite
the significant development in therapeutic strategies, the inevitable emergence of drug …

Kinase inhibitors (KIs) are important cancer drugs but often feature polypharmacology that is
molecularly not understood. This disconnect is particularly apparent in cancer entities such …

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment
of multiple histological subtypes of soft tissue sarcoma (STS). Initially developed as a small …

Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli.
Although cilia house a number of oncogenic molecules (including Smoothened, KRAS …

Sarcomas are a rare group of mesenchymal cancers comprising over 70 different
histological subtypes. For the majority of these diseases, the molecular understanding of the …