Electrochemical transformations catalyzed by cytochrome P450s and peroxidases

N Kumar, J He, JF Rusling - Chemical Society Reviews, 2023 - pubs.rsc.org
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …

Efficient heterologous expression of cytochrome P450 enzymes in microorganisms for the biosynthesis of natural products

B Hu, X Zhao, E Wang, J Zhou, J Li… - Critical Reviews in …, 2023 - Taylor & Francis
Natural products, a chemically and structurally diverse class of molecules, possess a wide
spectrum of biological activities, have been used therapeutically for millennia, and have …

Combining a Genetically Engineered Oxidase with Hydrogen‐Bonded Organic Frameworks (HOFs) for Highly Efficient Biocomposites

P Wied, F Carraro, JM Bolivar… - Angewandte Chemie …, 2022 - Wiley Online Library
Enzymes incorporated into hydrogen‐bonded organic frameworks (HOFs) via bottom‐up
synthesis are promising biocomposites for applications in catalysis and sensing. Here, we …

[HTML][HTML] Biocatalytic process intensification via efficient biocatalyst immobilization, miniaturization, and process integration

P Žnidaršič-Plazl - Current Opinion in Green and Sustainable Chemistry, 2021 - Elsevier
Despite their sustainability, the potential of biocatalytic processes in industrial production is
far from being realized. The main challenges in this field are the development of highly …

Whole-cell biocatalysis using cytochrome P450 monooxygenases for biotransformation of sustainable bioresources (fatty acids, fatty alkanes, and aromatic amino …

HA Park, G Park, W Jeon, JO Ahn, YH Yang… - Biotechnology …, 2020 - Elsevier
Cytochrome P450s (CYPs) are heme-thiolated enzymes that catalyze the oxidation of C
single bond H bonds in a regio and stereoselective manner. Activation of the non-activated …

An overview of cytochrome P450 immobilization strategies for drug metabolism studies, biosensing, and biocatalytic applications: challenges and opportunities

D Valikhani, JM Bolivar, JN Pelletier - ACS Catalysis, 2021 - ACS Publications
Cytochrome P450s (P450s or CYPs) are a large superfamily of ubiquitous heme proteins.
Consistent with their natural roles in oxidative metabolism of a broad range of substrates …

Choose Your Own Adventure: A Comprehensive Database of Reactions Catalyzed by Cytochrome P450 BM3 Variants

DJ Fansher, JN Besna, A Fendri, JN Pelletier - ACS catalysis, 2024 - ACS Publications
Cytochrome P450 BM3 monooxygenase is the topic of extensive research as many
researchers have evolved this enzyme to generate a variety of products. However, the …

MicroGelzymes: pH-independent immobilization of cytochrome P450 BM3 in microgels

M Nöth, L Hussmann, T Belthle, I El-Awaad… - …, 2020 - ACS Publications
Microgels are an emerging class of “ideal” enzyme carriers because of their chemical and
process stability, biocompatibility, and high enzyme loading capability. In this work, we …

On the relationship between structure and catalytic effectiveness in solid surface-immobilized enzymes: Advances in methodology and the quest for a single-molecule …

JM Bolivar, B Nidetzky - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2020 - Elsevier
The integration of enzymes with solid materials is important in many biotechnological
applications, including the use of immobilized enzymes for biocatalytic synthesis. The …

Co‐immobilization and colocalization of multi‐enzyme systems for the cell‐free biosynthesis of aminoalcohols

S Velasco‐Lozano, J Santiago‐Arcos… - …, 2020 - Wiley Online Library
The manufacturing of aminoalcohols is an appealing transformation for industrial
biocatalysis due to their high value as building blocks in synthetic chemistry. By co …