Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

T Olsson, LF Barcellos, L Alfredsson - Nature Reviews Neurology, 2017 - nature.com
Genetic predisposition to multiple sclerosis (MS) only explains a fraction of the disease risk;
lifestyle and environmental factors are key contributors to the risk of MS. Importantly, these …

[HTML][HTML] Brain health: time matters in multiple sclerosis

G Giovannoni, H Butzkueven, S Dhib-Jalbut… - Multiple sclerosis and …, 2016 - Elsevier
Introduction We present international consensus recommendations for improving diagnosis,
management and treatment access in multiple sclerosis (MS). Our vision is that these will be …

Associations of disease-modifying therapies with COVID-19 severity in multiple sclerosis

S Simpson-Yap, E De Brouwer, T Kalincik, N Rijke… - Neurology, 2021 - AAN Enterprises
Background and Objectives People with multiple sclerosis (MS) are a vulnerable group for
severe coronavirus disease 2019 (COVID-19), particularly those taking immunosuppressive …

Lifestyle and environmental factors in multiple sclerosis

L Alfredsson, T Olsson - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS),
because genetic predisposition only explains a fraction of the risk increase. There is strong …

Higher 25‐hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis

S Simpson Jr, B Taylor, L Blizzard… - Annals of …, 2010 - Wiley Online Library
Objective A protective association between higher vitamin D levels and the onset of multiple
sclerosis (MS) has been demonstrated; however, its role in modulating MS clinical course …

Risk factors for and management of cognitive dysfunction in multiple sclerosis

RHB Benedict, R Zivadinov - Nature Reviews Neurology, 2011 - nature.com
Cognitive impairment is common in multiple sclerosis (MS), especially when assessed by
neuropsychological tests that emphasize mental processing speed, episodic memory, and …

Smoke and autoimmunity: The fire behind the disease

C Perricone, M Versini, D Ben-Ami, S Gertel… - Autoimmunity …, 2016 - Elsevier
The association between smoke habit and autoimmunity has been hypothesized a long time
ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it …

Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis

B Wood, IAF Van Der Mei… - Multiple Sclerosis …, 2013 - journals.sagepub.com
Background: Anxiety, depression and fatigue are commonly reported by persons with
multiple sclerosis (PwMS). Objectives: We estimated the prevalence of each factor in a …

Smoking and multiple sclerosis: an updated meta-analysis

AE Handel, AJ Williamson, G Disanto, R Dobson… - PloS one, 2011 - journals.plos.org
Background Multiple sclerosis (MS) is a leading cause of disability in young adults.
Susceptibility to MS is determined by environmental exposure on the background of genetic …

Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms

C O'Gorman, R Lucas, B Taylor - International journal of molecular …, 2012 - mdpi.com
Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system
commonly affecting young adults. Pathologically, there are patches of inflammation …