Adaptive laboratory evolution (ALE) is an innovative approach for the generation of evolved
microbial strains with desired characteristics, by implementing the rules of natural selection …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

The wall gives a Saccharomyces cerevisiae cell its osmotic integrity; defines cell shape
during budding growth, mating, sporulation, and pseudohypha formation; and presents …

An extracellular matrix composed of a layered meshwork of β-glucans, chitin, and
mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae. This organelle …

The fungal cell wall is a complex structure composed of chitin, glucans and other polymers,
and there is evidence of extensive cross-linking between these components. The wall …

In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that
Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter …

Motivation: Microarray gene expression data has increasingly become the common data
source that can provide insights into biological processes at a system-wide level. One of the …

Transcription patterns shift dramatically as cells transit from one phase of the cell cycle to
another. To better define this transcriptional circuitry, we collected new microarray data …

The replicative life span (RLS) of Saccharomyces cerevisiae has been established as a
model for the genetic regulation of longevity despite the inherent difficulty of the RLS assay …

Cell-cycle control of transcription seems to be a universal feature of proliferating cells,
although relatively little is known about its biological significance and conservation between …