The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

Aims Loss-of-function mutations in ANGPTL3 are associated with beneficial effects on lipid
and glucose metabolism and reduced risk of coronary artery disease. Vupanorsen (AKCEA …

Background Epidemiologic and genomewide association studies have linked loss-of-
function variants in ANGPTL3, encoding angiopoietin-like 3, with low levels of plasma …

Background: Familial combined hypolipidemia, a Mendelian condition characterized by
substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the …

The positive relationship between increased levels of circulating triglycerides and
cardiovascular events has been observed for decades. Driven by genetic cohort studies …

Background: Hypertriglyceridemia is associated with increased cardiovascular risk and may
be caused by impaired lipoprotein clearance. Angiopoietin-like protein 3 (ANGPTL3) inhibits …

Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage.
Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein …

The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors,
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …

Congenital generalized lipodystrophy (CGL) is a heterogeneous autosomal recessive
disorder characterized by a near complete lack of adipose tissue from birth and, later in life …