Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …

Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

Identification of the gut microbiome compositions associated with disease has become a
research focus worldwide. Emerging evidence has revealed the presence of gut microbiota …

Biomarker research in Parkinson's disease (PD) has long been dominated by measuring
dopamine metabolites or alpha-synuclein in cerebrospinal fluid. However, these markers do …

Environmental toxins are harmful substances detrimental to humans. Constant exposure to
these fatal neurotoxins can cause various neurodegenerative disorders. Although …

The assembly of α-synuclein into cross-β structured amyloid fibers results in Lewy body
deposits and neuronal degeneration in Parkinson's disease patients. As the cell …

The plasma of Parkinson's disease (PD) patients may contain various altered metabolites
associated with the risk or progression of the disease. Characterization of the abnormal …

Pesticides have been used in agriculture, public health programs, and pharmaceuticals for
many decades. Though pesticides primarily target pests by affecting their nervous system …

Toxic aggregation of proteins and peptides into amyloid fibers is the basis of several human
diseases. In each disease, a particular peptide noncovalently assembles into long thin …

There are 78 loci associated with Parkinson's disease in the most recent genome-wide
association study (GWAS), yet the specific genes driving these associations are mostly …