Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional
blood flow during the cardiac cycle. However, this description does not adequately describe …

Heart valves (HVs) are cardiac structures whose physiological function is to ensure directed
blood flow through the heart over the cardiac cycle. While primarily passive structures that …

Numerous studies have suggested that medical image derived computational mechanics
models could be developed to reduce mortality and morbidity due to cardiovascular …

Although heart valve replacement is among the most common cardiovascular surgical
procedures, their outcome is often difficult to predict. One of the reasons is the design and …

This paper considers an anisotropic hyperelastic soft tissue model, originally proposed for
native valve tissue and referred to herein as the Lee–Sacks model, in an isogeometric thin …

Introduction: Replacement with a prosthetic device remains a major treatment option for the
patients suffering from heart valve disease, with prevalence growing resulting from an …

A set of multiscale simulations has been created to examine the dynamic behavior of the
human aortic valve (AV) at the cell, tissue, and organ length scales. Each model is fully three …

Transcatheter aortic valve replacement (TAVR) is an established treatment alternative to
surgical valve replacement in high-risk patients with severe symptomatic aortic stenosis. The …

It is a widely accepted axiom that localized concentration of mechanical stress and large
flexural deformation is closely related to the calcification and tissue degeneration in …

Theoretical models of the human heart valves are useful tools for understanding and
characterizing the dynamics of healthy and diseased valves. Enabled by advances in …