[HTML][HTML] A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

R Spector, SR Snodgrass, CE Johanson - Experimental neurology, 2015 - Elsevier
In this review, a companion piece to our recent examination of choroid plexus (CP), the
organ that secretes the cerebrospinal fluid (CSF), we focus on recent information in the …

Spaceflight-induced intracranial hypertension and visual impairment: pathophysiology and countermeasures

LF Zhang, AR Hargens - Physiological reviews, 2018 - journals.physiology.org
Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained
major risk for future long-duration spaceflight. NASA recently redefined this syndrome as …

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

FE Garrett-Bakelman, M Darshi, SJ Green, RC Gur… - Science, 2019 - science.org
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …

[HTML][HTML] Effects of spaceflight on astronaut brain structure as indicated on MRI

DR Roberts, MH Albrecht, HR Collins… - … England Journal of …, 2017 - Mass Medical Soc
Background There is limited information regarding the effects of spaceflight on the
anatomical configuration of the brain and on cerebrospinal fluid (CSF) spaces. Methods We …

[HTML][HTML] Long-term human spaceflight and inflammaging: Does it promote aging?

M Capri, M Conte, E Ciurca, C Pirazzini… - Ageing Research …, 2023 - Elsevier
Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

Neuro-consequences of the spaceflight environment

SD Mhatre, J Iyer, S Puukila, AM Paul… - Neuroscience & …, 2022 - Elsevier
As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …

Head-down tilt bed rest studies as a terrestrial analog for spaceflight associated neuro-ocular syndrome

J Ong, AG Lee, HE Moss - Frontiers in Neurology, 2021 - frontiersin.org
Astronauts who undergo prolonged periods of spaceflight may develop a unique
constellation of neuro-ocular findings termed Spaceflight Associated Neuro-Ocular …

Microgravity effects on the human brain and behavior: dysfunction and adaptive plasticity

KE Hupfeld, HR McGregor, PA Reuter-Lorenz… - Neuroscience & …, 2021 - Elsevier
Emerging plans for travel to Mars and other deep space destinations make it critical for us to
understand how spaceflight affects the human brain and behavior. Research over the past …

Persistent asymmetric optic disc swelling after long-duration space flight: implications for pathogenesis

TH Mader, CR Gibson, CA Otto… - Journal of Neuro …, 2017 - journals.lww.com
Background: Several ophthalmic findings including optic disc swelling, globe flattening and
choroidal folds have been observed in astronauts following long-duration space flight. The …

Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation

A Robin, A Van Ombergen, C Laurens… - Nature …, 2023 - nature.com
Astronauts in microgravity experience multi-system deconditioning, impacting their inflight
efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of …