Since their discovery and the advent of RNA interference, microRNAs have drawn enormous
attention because of their ubiquitous involvement in cellular pathways from life to death, from …

Personalized medicine is focused on research disciplines which contribute to the
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …

Aim: Vincristine is an important component of acute lymphoblastic leukemia (ALL) treatment
protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer …

Acute lymphoblastic leukemia (ALL) is a relatively rare disease in adults accounting for no
more than 20% of all cases of acute leukemia. By contrast with the pediatric population, in …

Acute lymphoblastic leukemia (ALL) is the major pediatric cancer in developed countries.
Although treatment outcome has improved owing to advances in chemotherapy, there is still …

Leprosy is a chronic neurodermatological disease caused by the bacillus Mycobacterium
leprae. Recent studies show that SNPs in genes related to miRNAs have been associated …

Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Although the
overall survival of children with ALL is now more than 90%, leukaemia remains one of the …

Methotrexate (MTX), a structurally related substance to folic acid, is an important
chemotherapeutic agent used for decades in the treatment of pediatric acute lymphoblastic …

Methotrexate (MTX) is an important component in the therapy used to treat childhood acute
lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key …

Glucocorticoid (GC) insensitivity occurs commonly in Graves' ophthalmopathy (GO), and GC
therapy is associated with major adverse effects. A reliable and easily accessible biomarker …