Cellular state landscape and herpes simplex virus type 1 infection progression are connected

MK Pietilä, JJ Bachmann, J Ravantti… - Nature …, 2023 - nature.com
Prediction, prevention and treatment of virus infections require understanding of cell-to-cell
variability that leads to heterogenous disease outcomes, but the source of this heterogeneity …

Ethosomal gel for topical administration of dimethyl fumarate in the treatment of HSV-1 infections

M Sicurella, W Pula, K Musiał… - International Journal of …, 2023 - mdpi.com
The infections caused by the HSV-1 virus induce lesions on the lips, mouth, face, and eye. In
this study, an ethosome gel loaded with dimethyl fumarate was investigated as a possible …

In vitro reconstitution of herpes simplex virus 1 fusion identifies low pH as a fusion co-trigger

JM Ramirez, AC Calderon-Zavala, A Balaram… - Mbio, 2023 - Am Soc Microbiol
Membrane fusion mediated by herpes simplex virus 1 (HSV-1) is a complex, multi-protein
process that is receptor triggered and can occur both at the cell surface and in endosomes …

Mangiferin-loaded smart gels for HSV-1 treatment

M Sicurella, M Sguizzato, R Cortesi, N Huang… - Pharmaceutics, 2021 - mdpi.com
Infections due to HSV-1 affect many people all over the world. To counteract this pathology,
usually characterized by perioral sores or by less frequent serious symptoms including …

Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome

AF Meier, K Tobler, R Leisi, A Lkharrazi, C Ros… - PLoS …, 2021 - journals.plos.org
Adeno-associated virus (AAV) genome replication only occurs in the presence of a co-
infecting helper virus such as adenovirus type 5 (AdV5) or herpes simplex virus type 1 (HSV …

Herpes simplex virus 1 coinfection modifies adeno-associated virus genome end recombination

AF Meier, K Tobler, K Michaelsen, B Vogt… - Journal of …, 2021 - Am Soc Microbiol
Wild-type adeno-associated virus (AAV) can only replicate in the presence of helper factors,
which can be provided by coinfecting helper viruses such as adenoviruses and …

[HTML][HTML] Growth, purification, and titration of oncolytic herpes simplex virus

HM Nguyen, N Sah, MRM Humphrey… - Journal of visualized …, 2021 - ncbi.nlm.nih.gov
Oncolytic viruses (OVs), such as the oncolytic herpes simplex virus (oHSV), are a rapidly
growing treatment strategy in the field of cancer immunotherapy. OVs, including oHSV …

In-vitro reconstitution of Herpes Simplex Virus 1 fusion identifies low pH as a fusion co-trigger

EE Heldwein, J Ramirez, A Calderon-Zavala… - bioRxiv, 2023 - biorxiv.org
Membrane fusion mediated by Herpes Simplex virus 1 (HSV-1) is a complex, multi-protein
process that is receptor-triggered and can occur both at the cell surface and in endosomes …

Adeno-associated virus (AAV2) can replicate its DNA by a rolling hairpin or rolling circle mechanism, depending on the helper virus.

A Lkharrazi, K Tobler, S Marti… - bioRxiv, 2023 - biorxiv.org
Adeno-associated virus type 2 (AAV2) is a small, non-pathogenic, helper virus-dependent
parvovirus with a single-stranded (ss) DNA genome of approximately 4.7 kb. AAV2 DNA …