Transcriptional regulation is achieved through combinatorial interactions between regulatory
elements in the human genome and a vast range of factors that modulate the recruitment …

Protein expression is a critical process in diverse biological systems. For Escherichia coli, a
widely employed microbial host in industrial catalysis and healthcare, researchers often face …

Gene activity is described by the time series of discrete, stochastic mRNA production events.
This transcriptional time series shows intermittent, bursty behavior. One consequence of this …

The genetic code is degenerate; thus, protein evolution does not uniquely determine the
coding sequence. One of the puzzles in evolutionary genetics is therefore to uncover …

Cell size varies during the cell cycle and in response to external stimuli. This requires the
tight coordination, or" scaling," of mRNA and protein quantities with the cell volume in order …

Gene expression in individual cells is highly variable and sporadic, often resulting in the
synthesis of mRNAs and proteins in bursts. Such bursting has important consequences for …

Cell-to-cell heterogeneity in gene expression and growth can have critical functional
consequences, such as determining whether individual bacteria survive or die following …

According to recent experimental evidence, promoter architecture, defined by the number,
strength and regulatory role of the operators that control transcription, plays a major role in …

The transcription factor vitamin D receptor (VDR) is the high affinity nuclear target of the
biologically active form of vitamin D3 (1, 25 (OH) 2D3). In order to identify pure genomic …

The rates of mRNA synthesis and decay determine the mRNA expression level. The two
processes are under coordinated control, which makes the measurements of these rates …