Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

Neuronal development in the human cerebral cortex is considerably prolonged compared
with that of other mammals. We explored whether mitochondria influence the species …

Regulatory T cells (Treg cells) are essential for immune tolerance, but also drive
immunosuppression in the tumour microenvironment. Therapeutic targeting of Treg cells in …

Brain metastases are refractory to therapies that control systemic disease in patients with
human epidermal growth factor receptor 2-positive breast cancer and the brain …

Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Polyamine synthesis represents one of the most profound metabolic changes during T cell
activation, but the biological implications of this are scarcely known. Here, we show that …

The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Cellular metabolism regulates immune cell activation, differentiation and effector functions,
but current metabolic approaches lack single-cell resolution and simultaneous …