Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

Abstract Adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase that acts on
RNA (ADAR) enzymes is a common RNA modification, preventing false activation of the …

Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …

Systematic exploration of cancer cell vulnerabilities can inform the development of novel
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of
adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The …

Herbert" Herb" Tabor, who celebrated his 100 th birthday this past year, served the Journal
of Biological Chemistry as a member of the Editorial Board beginning in 1961, as an …

Members of the ADAR family of double-stranded RNA–binding proteins regulate one of the
most abundant RNA modifications in humans, the deamination of adenosine to inosine …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Induction of interferons during viral infection is mediated by cellular proteins that recognise
viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA …