Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Osteoporosis is a significant public health problem, and a major cause of the disease is
estrogen deficiency following menopause in women. In addition, considerable evidence …

Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Cellular senescence is a fundamental mechanism by which cells remain metabolically
active yet cease dividing and undergo distinct phenotypic alterations, including upregulation …

Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts,
and osteoclasts are a source of bone formation-stimulating factors. Here we utilize …

The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age,
they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity …

Mechanical loading is the primary functional determinant of bone mass and architecture,
and osteocytes play a key role in translating mechanical signals into (re) modelling …

Estrogen deficiency is a seminal mechanism in the pathogenesis of osteoporosis. Mounting
evidence, however, establishes that cellular senescence, a fundamental mechanism that …