AGE-RAGE synergy influences programmed cell death signaling to promote cancer

BN Waghela, FU Vaidya, K Ranjan, AS Chhipa… - Molecular and Cellular …, 2021 - Springer
Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …

RAGE and its ligands: from pathogenesis to therapeutics

N Jangde, R Ray, V Rai - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma

X Chen, L Zhang, IY Zhang, J Liang, H Wang… - Cancer research, 2014 - AACR
Interaction of RAGE (the receptor for advanced glycation endproducts) with its ligands can
promote tumor progression, invasion, and angiogenesis. Although blocking RAGE signaling …

Role of receptor for advanced glycation end products (RAGE) and its ligands in cancer risk

S Yamagishi, T Matsui, K Fukami - Rejuvenation research, 2015 - liebertpub.com
Reducing sugars can react non-enzymatically with the amino groups of proteins, lipids, and
nucleic acids to initiate a complex series of rearrangements and dehydrations, and then to …

Zuojin Pill attenuates Helicobacter pylori-induced chronic atrophic gastritis in rats and improves gastric epithelial cells function in GES-1 cells

J Wen, S Wu, X Ma, Y Zhao - Journal of ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Zuojin pill (ZJP), a classical Chinese medicine formula,
has been widely applied in Chinese clinical practice for the treatment of gastric injury such …

Hyperglycemia-induced aberrant cell proliferation; a metabolic challenge mediated by protein O-GlcNAc modification

T Nagy, V Fisi, D Frank, E Kátai, Z Nagy, A Miseta - Cells, 2019 - mdpi.com
Chronic hyperglycemia has been associated with an increased prevalence of pathological
conditions including cardiovascular disease, cancer, or various disorders of the immune …

[HTML][HTML] Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

A Rojas, C Lindner, I Schneider… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Compelling shreds of evidence derived from both clinical and experimental research have
demonstrated the crucial contribution of receptor for advanced glycation end products …

SOSTDC1 inhibits follicular thyroid cancer cell proliferation, migration, and EMT via suppressing PI3K/Akt and MAPK/Erk signaling pathways

Q Zhou, J Chen, J Feng, Y Xu, W Zheng… - Molecular and cellular …, 2017 - Springer
The sclerostin domain containing protein 1 (SOSTDC1) is a cell signaling regulator involved
in cell physiology and pathology. SOSTDC1 is known to have a suppressive effect on certain …

Long non‐coding rna ager‐1 functionally upregulates the innate immunity gene ager and approximates its anti‐tumor effect in lung cancer

Z Pan, L Liu, W Nie, S Miggin, F Qiu… - Molecular …, 2018 - Wiley Online Library
Little is known about long non‐coding RNA (lncRNA) related to innate immunity in lung
cancer. The advanced glycosylation end‐product specific receptor (AGER) belongs to the …

Overexpression of the receptor for advanced glycation endproducts (RAGE) is associated with poor prognosis in gastric cancer

D Wang, T Li, G Ye, Z Shen, Y Hu, T Mou, J Yu, S Li… - PloS one, 2015 - journals.plos.org
Background The receptor for advanced glycation endproducts (RAGE) is an oncogenic
multidisciplinary trans-membranous receptor, which is overexpressed in multiple human …