Targeting tumor heterogeneity with neoantigen-based cancer vaccines

S Pounraj, S Chen, L Ma, R Mazzieri, R Dolcetti… - Cancer Research, 2024 - AACR
Neoantigen-based cancer vaccines have emerged as a promising immunotherapeutic
approach to treat cancer. Nevertheless, the high degree of heterogeneity in tumors poses a …

Charge neutralized poly (β-amino ester) polyplex nanoparticles for delivery of self-amplifying RNA

NK Dastgerdi, N Gumus, H Bayraktutan… - Nanoscale …, 2024 - pubs.rsc.org
Therapeutic self-amplifying RNA (saRNA) is a promising approach for disease treatment, as
it can be administered in lower doses than messenger RNA (mRNA) to achieve comparable …