Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Integrin adhesion complexes (IACs) have evolved over millions of years to integrate
metazoan cells physically with their microenvironment. It is presumed that the simultaneous …

Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

Integrins are cell adhesion receptors, which are typically transmembrane glycoproteins that
connect to the extracellular matrix (ECM). The function of integrins regulated by biochemical …

Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Macroautophagy/autophagy is a fundamental cellular degradation mechanism that
maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in …

Integrins are transmembrane receptors that coordinate extracellular matrix (ECM)–cell and
cell–cell interactions, signal transmission, gene expression, and cell function. The aberration …