Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …
offer diagnostic information that is otherwise accessible conventionally through invasive …
Liquid biopsies: genotyping circulating tumor DNA
LA Diaz Jr, A Bardelli - Journal of clinical oncology, 2014 - ascopubs.org
Genotyping tumor tissue in search of somatic genetic alterations for actionable information
has become routine practice in clinical oncology. Although these sequence alterations are …
has become routine practice in clinical oncology. Although these sequence alterations are …
Plasma DNA end-motif profiling as a fragmentomic marker in cancer, pregnancy, and transplantation
Plasma DNA fragmentomics is an emerging area of research covering plasma DNA sizes,
end points, and nucleosome footprints. In the present study, we found a significant increase …
end points, and nucleosome footprints. In the present study, we found a significant increase …
The nexus of cfDNA and nuclease biology
DSC Han, YMD Lo - Trends in Genetics, 2021 - cell.com
Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis
of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive …
of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive …
The diverse origins of circulating cell‐free DNA in the human body: a critical re‐evaluation of the literature
Since the detection of cell‐free DNA (cfDNA) in human plasma in 1948, it has been
investigated as a non‐invasive screening tool for many diseases, especially solid tumours …
investigated as a non‐invasive screening tool for many diseases, especially solid tumours …
Salivary biomarkers for oral squamous cell carcinoma diagnosis and follow-up: current status and perspectives
Oral cancer is the sixth most common cancer type in the world, and 90% of it is represented
by oral squamous cell carcinoma (OSCC). Despite progress in preventive and therapeutic …
by oral squamous cell carcinoma (OSCC). Despite progress in preventive and therapeutic …
The long and short of circulating cell-free DNA and the ins and outs of molecular diagnostics
P Jiang, YMD Lo - Trends in Genetics, 2016 - cell.com
The discovery of cell-free tumor and fetal DNA molecules in the plasma of cancer patients
and pregnant women, respectively, has opened up exciting opportunities in molecular …
and pregnant women, respectively, has opened up exciting opportunities in molecular …
Cell-free DNA fragmentomics in liquid biopsy
SC Ding, YMD Lo - Diagnostics, 2022 - mdpi.com
Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of
noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma …
noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma …
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …
Sterile inflammation and pregnancy complications: a review
M Nadeau-Vallée, D Obari, J Palacios… - …, 2016 - rep.bioscientifica.com
Inflammation is essential for successful embryo implantation, pregnancy maintenance and
delivery. In the last decade, important advances have been made in regard to endogenous …
delivery. In the last decade, important advances have been made in regard to endogenous …