Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition,
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Spermidine (SPD) delays age-related pathologies in various organisms. SPD
supplementation overcame the impaired immunotherapy against tumors in aged mice by …

BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …

Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by
irregular mitochondrial morphology, insufficient ATP production, accumulation of …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …