Correlates of protection (CoPs) are increasingly important in the development and licensure
of vaccines. Although the study of CoPs was initially directed at identifying a single immune …

Many unknowns exist about human immune responses to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have …

Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …

Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …

Detection of Ag-specific CD4+ T cells is central to the study of many human infectious
diseases, vaccines, and autoimmune diseases. However, such cells are generally rare and …

“Strep throat” is highly prevalent among children, yet it is unknown why only some children
develop recurrent tonsillitis (RT), a common indication for tonsillectomy. To gain insights into …

Background Prediction of T cell immunogenicity is a topic of considerable interest, both in
terms of basic understanding of the mechanisms of T cells responses and in terms of …

In the mid-1990s, whole-cell pertussis (wP) vaccines were associated with local and
systemic adverse events that prompted their replacement with acellular pertussis (aP) …

Pertussis is resurgent in some countries, particularly those in which children receive
acellular pertussis (aP) vaccines in early infancy and boosters later in life. Immunologic …

Background Dengue is a major public health problem worldwide. Assessment of adaptive
immunity is important to understanding immunopathology and to define correlates of …