Peptide-based drug-delivery systems in biotechnological applications: recent advances and perspectives

D Tesauro, A Accardo, C Diaferia, V Milano, J Guillon… - Molecules, 2019 - mdpi.com
Peptides of natural and synthetic sources are compounds operating in a wide range of
biological interactions. They play a key role in biotechnological applications as both …

Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development

DC Drummond, CO Noble, ME Hayes, JW Park… - Journal of …, 2008 - Elsevier
Liposomes represent a widely varied and malleable class of drug carriers generally
characterized by the presence of one or more amphiphile bilayers enclosing an interior …

Synthesis of biomolecule‐modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells

DP Ferris, J Lu, C Gothard, R Yanes, CR Thomas… - Small, 2011 - Wiley Online Library
Synthetic methodologies integrating hydrophobic drug delivery and biomolecular targeting
with mesoporous silica nanoparticles are described. Transferrin and cyclic‐RGD peptides …

A biomimetic microfluidic tumor microenvironment platform mimicking the EPR effect for rapid screening of drug delivery systems

Y Tang, F Soroush, JB Sheffield, B Wang… - Scientific reports, 2017 - nature.com
Real-time monitoring of tumor drug delivery in vivo is a daunting challenge due to the
heterogeneity and complexity of the tumor microenvironment. In this study, we developed a …

Anti-cancer therapies targeting the tumor stroma

V Hofmeister, D Schrama, JC Becker - Cancer Immunology …, 2008 - Springer
For anti-tumor therapy different strategies have been employed, eg, radiotherapy,
chemotherapy, or immunotherapy. Notably, these approaches do not only address the tumor …

The development of site-specific drug delivery nanocarriers based on receptor mediation

X Wang, S Li, Y Shi, X Chuan, J Li, T Zhong… - Journal of controlled …, 2014 - Elsevier
Since they were first reported in 1980, site-specific drug delivery nanocarriers have
progressed greatly with the development of nanotechnology and biotechnology, especially …

Radionuclide carriers for targeting of cancer

S Sofou - International journal of nanomedicine, 2008 - Taylor & Francis
This review describes strategies for the delivery of therapeutic radionuclides to tumor sites.
Therapeutic approaches are summarized in terms of tumor location in the body, and tumor …

Application of pharmacokinetic and pharmacodynamic analysis to the development of liposomal formulations for oncology

S Ait-Oudhia, DE Mager, RM Straubinger - Pharmaceutics, 2014 - mdpi.com
Liposomal formulations of anticancer agents have been developed to prolong drug
circulating lifetime, enhance anti-tumor efficacy by increasing tumor drug deposition, and …

Immunoliposomes

E Paszko, MO Senge - Current medicinal chemistry, 2012 - ingentaconnect.com
Since their discovery by Bangham about 50 years ago, liposomes have become promising
tools in drug delivery systems. This has increased the therapeutic index of many drugs, and …

Targeted multidrug delivery system to overcome chemoresistance in breast cancer

Y Tang, F Soroush, Z Tong, MF Kiani… - International journal of …, 2017 - Taylor & Francis
Chemotherapy has been widely used in breast cancer patients to reduce tumor size.
However, most anticancer agents cannot differentiate between cancerous and normal cells …