Cucurbiturils: from synthesis to high-affinity binding and catalysis
In the wide area of supramolecular chemistry, cucurbit [n] urils (CBn) present themselves as
a young family of molecular containers, able to form stable complexes with various guests …
a young family of molecular containers, able to form stable complexes with various guests …
Applications of cucurbiturils in medicinal chemistry and chemical biology
The supramolecular chemistry of cucurbit [n] urils (CB n) has been rapidly developing to
encompass diverse medicinal applications, including drug formulation and delivery …
encompass diverse medicinal applications, including drug formulation and delivery …
Fluorescent dyes and their supramolecular host/guest complexes with macrocycles in aqueous solution
The fluorescence of organic molecules depends sensitively on their environment.
Fluorescent dyes have accordingly become popular molecular probes not only to determine …
Fluorescent dyes have accordingly become popular molecular probes not only to determine …
Cucurbituril chemistry: a tale of supramolecular success
This review highlights the past six year advances in the blossoming field of cucurbit [n] uril
chemistry. Because of their exceptional recognition properties in aqueous medium, these …
chemistry. Because of their exceptional recognition properties in aqueous medium, these …
Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals
D Ma, G Hettiarachchi, D Nguyen, B Zhang… - Nature …, 2012 - nature.com
Abstract The solubility characteristics of 40–70% of new drug candidates are so poor that
they cannot be formulated on their own, so new methods for increasing drug solubility are …
they cannot be formulated on their own, so new methods for increasing drug solubility are …
Deep inside cucurbiturils: physical properties and volumes of their inner cavity determine the hydrophobic driving force for host–guest complexation
WM Nau, M Florea, KI Assaf - Israel Journal of Chemistry, 2011 - Wiley Online Library
Abstract Cucurbit [n] urils (CBn) bind guest molecules through a combination of electrostatic
interactions with the carbonyl rims and hydrophobic interactions with the inner cavity …
interactions with the carbonyl rims and hydrophobic interactions with the inner cavity …
The strategic use of supramolecular pKa shifts to enhance the bioavailability of drugs
Macrocyclic hosts of the cyclodextrin, sulfonatocalixarene, and cucurbituril type can be
employed as discrete supramolecular drug delivery systems, thereby complementing …
employed as discrete supramolecular drug delivery systems, thereby complementing …
Toxicity of cucurbit [7] uril and cucurbit [8] uril: an exploratory in vitro and in vivo study
Cucurbit [n] urils (CB [n]) are potential stabilizing, solubilizing, activating, and delivering
agents for drugs. The toxicity of the macrocyclic host molecules cucurbit [7] uril (CB [7]), the …
agents for drugs. The toxicity of the macrocyclic host molecules cucurbit [7] uril (CB [7]), the …
Supramolecular polymeric biomaterials
Polymeric chains crosslinked through supramolecular interactions—directional and
reversible non-covalent interactions—compose an emerging class of modular and tunable …
reversible non-covalent interactions—compose an emerging class of modular and tunable …
The Potential of Cucurbit[n]urils in Drug Delivery
S Walker, R Oun, FJ McInnes… - Israel Journal of …, 2011 - Wiley Online Library
In this paper we review cucurbit [n] urils (CB [n]), a relatively new family of macrocycles that
has shown potential in improving drug delivery. Encapsulation of drugs within the …
has shown potential in improving drug delivery. Encapsulation of drugs within the …