Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

High-throughput transcriptomic profiling approaches have revealed that alternative splicing
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …

Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most
common extracranial tumor of childhood. By sequencing transcriptomes of low-and high-risk …

In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the
epithelium. These cells are believed to provide trophic signals to epithelial cell populations …

Protein complexes that contain chromatin-modifying enzymes have an important role in
regulating gene expression. Recent studies have shown that a single transcription factor, the …

The neuronal repressor REST (RE1-silencing transcription factor; also called NRSF) is
expressed at high levels in mouse embryonic stem (ES) cells, but its role in these cells is …

The RE1-silencing transcription factor (REST, also known as NRSF) is a master repressor of
neuronal gene expression and neuronal programmes in non-neuronal lineages,,. Recently …

Medulloblastoma is an aggressive brain malignancy with high incidence in childhood.
Current treatment approaches have limited efficacy and severe side effects. Therefore, new …

The adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner
ear generally leads to permanent hearing loss in humans. Here, we present that …

Given that miR-124 is preferentially expressed in differentiating and mature neurons and
external granule cells of cerebellum are thought to be cells-of-origins of medulloblastomas …