During pregnancy, several tightly coordinated and regulated processes take place to enable
proper fetal development and gestational success. The formation and development of the …

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian
reproduction due to their involvement in the onset of puberty and control of the hypothalamic …

Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

BACKGROUND Initially identified as suppressors of metastasis in various types of cancer,
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …

Rationale: Idiopathic or heritable pulmonary arterial hypertension is characterized by loss
and obliteration of lung vasculature. Endothelial cell dysfunction is pivotal to the …

Background During pregnancy, trophoblast cell invasion needs to be finely controlled.
Aberrant trophoblast cell invasion is associated with placental diseases. Epidermal growth …

Kisspeptin (KISS1) is encoded by the KISS1 gene and was initially found to be a repressor
of metastasis. Natural mutations in the KISS1 receptor gene (KISS1R) were subsequently …

Background Tightly regulation of extravillous cytotrophoblast (EVT) cell invasion is critical for
the placentation and establishment of a successful pregnancy. Insufficient EVT cell invasion …

Kisspeptin and its receptor are central to reproductive health acting as key regulators of the
reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator …

Objective To validate the ability of serum kisspeptin-54 to discriminate between first-trimester
viable pregnancies and miscarriages. Design Case-control study. Setting Academic medical …