[HTML][HTML] Amino acids in the regulation of aging and aging-related diseases

CA Canfield, PC Bradshaw - Translational Medicine of Aging, 2019 - Elsevier
Amino acids are the building blocks of protein, but also play important cellular signaling
roles. The mechanisms through which altered levels of many amino acids are sensed and …

[HTML][HTML] Carnosine and beta-alanine supplementation in human medicine: narrative review and critical assessment

O Cesak, J Vostalova, A Vidlar, P Bastlova… - Nutrients, 2023 - mdpi.com
The dipeptide carnosine is a physiologically important molecule in the human body,
commonly found in skeletal muscle and brain tissue. Beta-alanine is a limiting precursor of …

[HTML][HTML] Anti-cancer actions of carnosine and the restoration of normal cellular homeostasis

MD Turner, C Sale, AC Garner, AR Hipkiss - Biochimica et Biophysica Acta …, 2021 - Elsevier
Carnosine is a naturally occurring dipeptide found in meat. Alternatively it can be formed
through synthesis from the amino acids, β-alanine and L-histidine. Carnosine has long been …

[HTML][HTML] Non-enzymatic molecular damage as a prototypic driver of aging

A Golubev, AD Hanson, VN Gladyshev - Journal of Biological Chemistry, 2017 - ASBMB
The chemical potentialities of metabolites far exceed metabolic requirements. The required
potentialities are realized mostly through enzymatic catalysis. The rest are realized …

Effects of combined carnosine and ultra-high pressure on the inhibition of fishy off-odor of snakehead fillets and the possible mechanism

L Sun, J Lv, Y Liu, M Zang, P Li, D Wang, Y Zhu, W Xu - Food Chemistry, 2022 - Elsevier
The effects of combined application of ultra-high pressure (300 Mpa, 900 s) and carnosine
on the inhibition of fishy off-odor from snakehead meat were investigated. Results showed …

Gerontechnological factors affecting successful aging of elderly

F Özsungur - The Aging Male, 2020 - Taylor & Francis
In this article, the gerontological factors affecting the successful aging of the elderly have
been uncovered, the quality of life and successful aging issues have been related to …

Carnosine decreased oxidation and glycation products in serum and liver of high‐fat diet and low‐dose streptozotocin‐induced diabetic rats

AF Aydın, İ Bingül, C Küçükgergin… - International journal …, 2017 - Wiley Online Library
High‐fat diet (HFD) and low‐dose streptozotocin (STZ)‐treated rats provide useful animal
model for type II diabetes mellitus. Oxidative stress and advanced glycation end products …

Integration of mass spectrometry imaging and machine learning visualizes region-specific age-induced and drug-target metabolic perturbations in the brain

T Vallianatou, R Shariatgorji, A Nilsson… - ACS Chemical …, 2021 - ACS Publications
Detailed metabolic imaging of specific brain regions in early aging may expose
pathophysiological mechanisms and indicate effective neuropharmacological targets in the …

[HTML][HTML] Anti-cancer effects of carnosine—A dipeptide molecule

MD Prakash, S Fraser, JC Boer, M Plebanski… - Molecules, 2021 - mdpi.com
Background: Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory,
antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a …

Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease

MM Sonsalla, DW Lamming - Geroscience, 2023 - Springer
Alzheimer's disease (AD) is an age-associated neurodegenerative disease. As the
population ages, the increasing prevalence of AD threatens massive healthcare costs in the …