PET imaging of neuroinflammation in neurological disorders
A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …
characterise the inflammatory processes underlying various diseases and to inform the …
[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
S Parhizkar, T Arzberger, M Brendel… - Nature …, 2019 - nature.com
Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are
associated with late-onset Alzheimer's disease (AD). We demonstrate that amyloid plaque …
associated with late-onset Alzheimer's disease (AD). We demonstrate that amyloid plaque …
Neuroimaging biomarkers for Alzheimer's disease
F Márquez, MA Yassa - Molecular neurodegeneration, 2019 - Springer
Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …
SPECT and PET imaging in Alzheimer's disease
V Valotassiou, J Malamitsi, J Papatriantafyllou… - Annals of nuclear …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) …
common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) …
Chronic inflammation in multiple sclerosis—seeing what was always there
PM Matthews - Nature Reviews Neurology, 2019 - nature.com
Activation of innate immune cells and other compartmentalized inflammatory cells in the
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …
Imaging neuroinflammation in neurodegenerative disorders
Neuroinflammation plays a major role in the etiopathology of neurodegenerative diseases,
including Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, and …
including Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, and …
TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma
NL Albert, M Unterrainer, DF Fleischmann… - European journal of …, 2017 - Springer
Objective The 18-kDa mitochondrial translocator protein (TSPO) was reported to be
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …
Sifting through the surfeit of neuroinflammation tracers
The first phase of molecular brain imaging of microglial activation in neuroinflammatory
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the …
[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …