Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Changing epidemiology of hepatocellular carcinoma in Asia

C Zhang, Y Cheng, S Zhang, J Fan, Q Gao - Liver International, 2022 - Wiley Online Library
Liver cancer is the fifth most common cancer and the second leading cause of malignant
death in Asia, and Asia reports 72.5% of the world's cases in 2020. As the most common …

Lenvatinib combined with transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma: a phase III, randomized clinical trial …

Z Peng, W Fan, B Zhu, G Wang, J Sun… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Lenvatinib (LEN) is a first-line therapy for patients with advanced hepatocellular
carcinoma (HCC); however, it has shown modest survival benefits. Therefore, we aimed to …

Arterial chemotherapy of oxaliplatin plus fluorouracil versus sorafenib in advanced hepatocellular carcinoma: a biomolecular exploratory, randomized, phase III trial …

N Lyu, X Wang, JB Li, JF Lai, QF Chen, SL Li… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Interventional hepatic arterial infusion chemotherapy of infusional fluorouracil,
leucovorin, and oxaliplatin (HAIC-FO) displayed an encouraging safety profile and antitumor …

Tislelizumab vs sorafenib as first-line treatment for unresectable hepatocellular carcinoma: a phase 3 randomized clinical trial

S Qin, M Kudo, T Meyer, Y Bai, Y Guo, Z Meng… - JAMA …, 2023 - jamanetwork.com
Importance Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality,
and additional first-line treatments are needed. The programmed cell death protein 1 …

Lenvatinib, toripalimab, plus hepatic arterial infusion chemotherapy versus lenvatinib alone for advanced hepatocellular carcinoma

MK He, RB Liang, Y Zhao, YJ Xu… - … in medical oncology, 2021 - journals.sagepub.com
Background: Lenvatinib is the first-line treatment for advanced hepatocellular carcinoma, but
prognosis is still unsatisfactory. Recently, hepatic arterial infusion chemotherapy (HAIC), and …

The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines: 2022 update

N Wen, Y Cai, F Li, H Ye, W Tang, P Song… - Bioscience …, 2022 - jstage.jst.go.jp
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second
leading cause of cancer-related mortality worldwide. This review is an updated version that …

Treatment and the prognosis of hepatocellular carcinoma in Asia

T Torimura, H Iwamoto - Liver International, 2022 - Wiley Online Library
Hepatocellular carcinoma is the most common type of malignant tumour in Asia. Treatment
is decided according to the staging system with information on tumour burden and liver …

Defects in macrophage reprogramming in cancer therapy: the negative impact of PD-L1/PD-1

H Cai, Y Zhang, J Wang, J Gu - Frontiers in immunology, 2021 - frontiersin.org
Classically activated M1 macrophages and alternatively activated M2 macrophages are two
polarized subsets of macrophages at the extreme ends of a constructed continuum. In the …

Combination of ablation and immunotherapy for hepatocellular carcinoma: where we are and where to go

K Wang, C Wang, H Jiang, Y Zhang, W Lin… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide and is increasing in incidence. Local ablative therapy plays a leading role in HCC …