The folding of proteins into functional nanoparticles with defined 3D structures has inspired
chemists to create simple synthetic systems mimicking protein properties. The folding of …

The performance of a protein depends on its correct folding to the final functional native
form. Hence, understanding the process of protein folding has remained an important field of …

There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

The presence of insoluble protein deposits in tissues and organs is a hallmark of many
human pathologies. In addition, the formation of protein aggregates is considered one of the …

GdmCl and NaSCN are two strong chaotropic salts commonly used in protein folding and
stability studies, but their microscopic mechanisms remain enigmatic. Here, by CD and …

We developed a method for implicit solvent molecular dynamics simulations of proteins in
solvent mixtures (model with implicit solvation thermodynamics, MIST). The MIST method …

Protein folding is a process in which a polypeptide must undergo folding process to obtain
its three-dimensional structure. Thermodynamically, it is a process of enthalpy to overcome …

Site-directed spin labeling electron paramagnetic resonance (SDSL-EPR) using nitroxide
spin labels is a well-established technology for mapping site-specific secondary and tertiary …

Structural biology of enzymatic catalysis posits that structure defines function. This idea is
deeply rooted in the “lock-and-key” perspective of the enzyme action. Although some …