MALDI-TOF mass spectrometry in clinical analysis and research
In the decade after being awarded the Nobel Prize in Chemistry in 2002, matrix-assisted
laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been …
laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been …
Advances in MALDI mass spectrometry imaging single cell and tissues
X Zhu, T Xu, C Peng, S Wu - Frontiers in Chemistry, 2022 - frontiersin.org
Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …
Analyzing cell-type-specific dynamics of metabolism in kidney repair
A common drawback of metabolic analyses of complex biological samples is the inability to
consider cell-to-cell heterogeneity in the context of an organ or tissue. To overcome this …
consider cell-to-cell heterogeneity in the context of an organ or tissue. To overcome this …
Spatial metabolomics principles and application to cancer research
M Planque, S Igelmann, AMF Campos… - Current Opinion in …, 2023 - Elsevier
Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics.
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …
Understanding the central role of citrate in the metabolism of cancer cells and tumors: an update
Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …
High-Mannose N-Glycans as Malignant Progression Markers in Early-Stage Colorectal Cancer
F Boyaval, H Dalebout, R Van Zeijl, W Wang… - Cancers, 2022 - mdpi.com
Simple Summary The detection of colorectal cancer (CRC) at an early stage is increasing
due to the implementation of screening programs. Local excision of early CRC is potentially …
due to the implementation of screening programs. Local excision of early CRC is potentially …
Evaluation of 6 MALDI-matrices for 10 μm lipid imaging and on-tissue MSn with AP-MALDI-Orbitrap
TB Angerer, J Bour, JL Biagi… - Journal of the …, 2022 - ACS Publications
Mass spectrometry imaging is a technique uniquely suited to localize and identify lipids in a
tissue sample. Using an atmospheric pressure (AP-) matrix-assisted laser desorption …
tissue sample. Using an atmospheric pressure (AP-) matrix-assisted laser desorption …
Emerging metabolomic tools to study cancer metastasis
Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role
of metabolism during metastasis has been limited by the development of robust and …
of metabolism during metastasis has been limited by the development of robust and …
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples
H Liu, Y Pan, C Xiong, J Han, X Wang, J Chen… - TrAC Trends in Analytical …, 2022 - Elsevier
Endogenous small molecules play important roles in biological processes and are closely
related to the occurrence and development of many diseases. Profiling of spatial distribution …
related to the occurrence and development of many diseases. Profiling of spatial distribution …
Multiplex protein imaging in tumour biology
N de Souza, S Zhao, B Bodenmiller - Nature Reviews Cancer, 2024 - nature.com
Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …
experimental and analytical methods now make it possible to image protein markers in …