In the decade after being awarded the Nobel Prize in Chemistry in 2002, matrix-assisted
laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been …

Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

A common drawback of metabolic analyses of complex biological samples is the inability to
consider cell-to-cell heterogeneity in the context of an organ or tissue. To overcome this …

Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics.
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Simple Summary The detection of colorectal cancer (CRC) at an early stage is increasing
due to the implementation of screening programs. Local excision of early CRC is potentially …

Mass spectrometry imaging is a technique uniquely suited to localize and identify lipids in a
tissue sample. Using an atmospheric pressure (AP-) matrix-assisted laser desorption …

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role
of metabolism during metastasis has been limited by the development of robust and …

Endogenous small molecules play important roles in biological processes and are closely
related to the occurrence and development of many diseases. Profiling of spatial distribution …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …