Integrated MRI-guided radiotherapy—opportunities and challenges

PJ Keall, C Brighi, C Glide-Hurst, G Liney… - Nature Reviews …, 2022 - nature.com
MRI can help to categorize tissues as malignant or non-malignant both anatomically and
functionally, with a high level of spatial and temporal resolution. This non-invasive imaging …

[HTML][HTML] Magnetic resonance imaging-guided adaptive radiation therapy: a “game changer” for prostate treatment?

AU Pathmanathan, NJ van As, LGW Kerkmeijer… - International Journal of …, 2018 - Elsevier
Radiation therapy to the prostate involves increasingly sophisticated delivery techniques
and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per …

AAPM Task Group 264: The safe clinical implementation of MLC tracking in radiotherapy

PJ Keall, A Sawant, RI Berbeco, JT Booth… - Medical …, 2021 - Wiley Online Library
The era of real‐time radiotherapy is upon us. Robotic and gimbaled linac tracking are
clinically established technologies with the clinical realization of couch tracking in …

See, think, and act: real-time adaptive radiotherapy

P Keall, P Poulsen, JT Booth - Seminars in radiation oncology, 2019 - Elsevier
The world is embracing the information age, with real-time data at hand to assist with many
decisions. Similarly, in cancer radiotherapy we are inexorably moving toward using …

The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator

PJ Keall, DT Nguyen, R O'Brien, V Caillet… - Radiotherapy and …, 2018 - Elsevier
Purpose Until now, real-time image guided adaptive radiation therapy (IGART) has been the
domain of dedicated cancer radiotherapy systems. The purpose of this study was to clinically …

The first patient treatment of electromagnetic-guided real time adaptive radiotherapy using MLC tracking for lung SABR

JT Booth, V Caillet, N Hardcastle, R O'Brien… - Radiotherapy and …, 2016 - Elsevier
Background and purpose Real time adaptive radiotherapy that enables smaller irradiated
volumes may reduce pulmonary toxicity. We report on the first patient treatment of …

First experimental investigation of simultaneously tracking two independently moving targets on an MRI‐linac using real‐time MRI and MLC tracking

PZY Liu, B Dong, DT Nguyen, Y Ge… - Medical …, 2020 - Wiley Online Library
Purpose High quality radiotherapy is challenging in cases where multiple targets with
independent motion are simultaneously treated. A real‐time tumor tracking system that can …

Real‐time radial reconstruction with domain transform manifold learning for MRI‐guided radiotherapy

DEJ Waddington, N Hindley, N Koonjoo… - Medical …, 2023 - Wiley Online Library
Background MRI‐guidance techniques that dynamically adapt radiation beams to follow
tumor motion in real time will lead to more accurate cancer treatments and reduced …

Respiratory motion-management in stereotactic body radiation therapy for lung cancer–A dosimetric comparison in an anthropomorphic lung phantom (LuCa)

S Ehrbar, R Perrin, M Peroni, K Bernatowicz… - Radiotherapy and …, 2016 - Elsevier
Background and purpose The objective of this study was to compare the latest respiratory
motion-management strategies, namely the internal-target-volume (ITV) concept, the mid …

Stereotactic body radiation therapy with optional focal lesion ablative microboost in prostate cancer: Topical review and multicenter consensus

C Draulans, R De Roover, UA van der Heide… - Radiotherapy and …, 2019 - Elsevier
Stereotactic body radiotherapy (SBRT) for prostate cancer (PCa) is gaining interest by the
recent publication of the first phase III trials on prostate SBRT and the promising results of …