Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future
X Zhou, S Ramachandran, M Mann, DL Popkin - Viruses, 2012 - mdpi.com
Lymphocytic choriomeningitis virus (LCMV) is a common infection of rodents first identified
over eighty years ago in St. Louis, MO, USA It is best known for its application in …
over eighty years ago in St. Louis, MO, USA It is best known for its application in …
Structural cells are key regulators of organ-specific immune responses
The mammalian immune system implements a remarkably effective set of mechanisms for
fighting pathogens. Its main components are haematopoietic immune cells, including …
fighting pathogens. Its main components are haematopoietic immune cells, including …
Type I interferons: diversity of sources, production pathways and effects on immune responses
M Swiecki, M Colonna - Current opinion in virology, 2011 - Elsevier
Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells
that interfere with virus replication and promote an antiviral state. Innate and adaptive …
that interfere with virus replication and promote an antiviral state. Innate and adaptive …
Persistent LCMV infection is controlled by blockade of type I interferon signaling
During persistent viral infections, chronic immune activation, negative immune regulator
expression, an elevated interferon signature, and lymphoid tissue destruction correlate with …
expression, an elevated interferon signature, and lymphoid tissue destruction correlate with …
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
BH Zinselmeyer, S Heydari, C Sacristán… - Journal of Experimental …, 2013 - rupress.org
Immune responses to persistent viral infections and cancer often fail because of intense
regulation of antigen-specific T cells—a process referred to as immune exhaustion. The …
regulation of antigen-specific T cells—a process referred to as immune exhaustion. The …
Plasmacytoid dendritic cells control T-cell response to chronic viral infection
L Cervantes-Barragan, KL Lewis… - Proceedings of the …, 2012 - National Acad Sciences
Infections with persistent viruses are a frequent cause of immunosuppression, autoimmune
sequelae, and/or neoplastic disease. Plasmacytoid dendritic cells (pDCs) are innate …
sequelae, and/or neoplastic disease. Plasmacytoid dendritic cells (pDCs) are innate …
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection
Although type I interferon (IFN-I) is thought to be beneficial against microbial infections,
persistent viral infections are characterized by high interferon signatures suggesting that IFN …
persistent viral infections are characterized by high interferon signatures suggesting that IFN …
Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection
Summary Type I interferon (IFN-I) promotes antiviral CD8+ T cell responses, but the
contribution of different IFN-I sources and signaling pathways are ill defined. While …
contribution of different IFN-I sources and signaling pathways are ill defined. While …
[HTML][HTML] Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity
BA Norris, LS Uebelhoer, HI Nakaya, AA Price… - Immunity, 2013 - cell.com
Resolution of acute and chronic viral infections requires activation of innate cells to initiate
and maintain adaptive immune responses. Here we report that infection with acute …
and maintain adaptive immune responses. Here we report that infection with acute …
The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production
Arenavirus pathogens cause a wide spectrum of diseases in humans ranging from central
nervous system disease to lethal hemorrhagic fevers with few treatment options. The reason …
nervous system disease to lethal hemorrhagic fevers with few treatment options. The reason …