Heart-rate variability (HRV) is frequently introduced as mirroring imbalances within the
autonomous nerve system. Many investigations are based on the paradigm that increased …

Conventional approaches to developing biomaterials and implants require intuitive tailoring
of manufacturing protocols and biocompatibility assessment. This leads to longer …

Single-cell techniques are advancing rapidly and are yielding unprecedented insight into
cellular heterogeneity. Mapping the gene regulatory networks (GRNs) underlying cell states …

Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells
harboring identical genomes show a wide variety of behaviors in multicellular organisms …

In the recent years, the vast amount of genetic information generated by new-generation
approaches, have led to the need of new data handling methods. The integrative analysis of …

Gene regulatory network (GRN) is the important mechanism of maintaining life process,
controlling biochemical reaction and regulating compound level, which plays an important …

Transcriptional regulatory networks (TRNs) provide insight into cellular behavior by
describing interactions between transcription factors (TFs) and their gene targets. The assay …

New fundamental discoveries in stem cell biology have yielded potentially transformative
regenerative therapeutics. However, widespread implementation of stem-cell-derived …

This paper focuses on inferring a general class of hidden Markov models (HMMs) using data
acquired from experts. Expert-acquired data contain decisions/actions made by …