Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association …

The red blood cell depends solely on the anaerobic conversion of glucose by the Embden-
Meyerhof pathway for the generation and storage of high-energy phosphates, which is …

Gene expression is tightly regulated, with many genes exhibiting cell-specific silencing
when their protein product would disrupt normal cellular function. This silencing is largely …

OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is
influenced by average glycemia over a 2-to 3-month period. Genetic factors affecting …

Red blood cells (RBCs) contain large amounts of iron and operate in highly oxygenated
tissues. As a result, these cells encounter a continuous oxidative stress. Protective …

Glycated hemoglobin A1c (HbA1c) is used as a measure of glycemic control and also as a
diagnostic criterion for diabetes. To discover novel loci harboring common variants …

Molecular abnormalities of erythroenzymopathies associated with hereditary hemolytic
anemia have been determined by means of molecular biology. Pyruvate kinase (PK) …

Significance: Hexokinases are key enzymes that are responsible for the first reaction of
glycolysis, but they also moonlight other cellular processes, including mitochondrial redox …

Purpose.: To identify the cause of retinitis pigmentosa (RP) in UTAD003, a large, six-
generation Louisiana family with autosomal dominant retinitis pigmentosa (adRP). Methods …

Abstract Hereditary Motor and Sensory Neuropathy–Russe (HMSNR) is a severe autosomal
recessive disorder, identified in the Gypsy population. Our previous studies mapped the …