Functional ultrasound imaging: a new imaging modality for neuroscience

T Deffieux, C Demené, M Tanter - Neuroscience, 2021 - Elsevier
Ultrasound sensitivity to slow blood flow motion gained two orders of magnitude in the last
decade thanks to the advent of ultrafast ultrasound imaging at thousands of frames per …

Functional ultrasound neuroimaging

G Montaldo, A Urban, E Macé - Annual Review of Neuroscience, 2022 - annualreviews.org
Functional ultrasound (fUS) is a neuroimaging method that uses ultrasound to track changes
in cerebral blood volume as an indirect readout of neuronal activity at high spatiotemporal …

Whole-brain functional ultrasound imaging in awake head-fixed mice

C Brunner, M Grillet, A Urban, B Roska, G Montaldo… - Nature …, 2021 - nature.com
Most brain functions engage a network of distributed regions. Full investigation of these
functions thus requires assessment of whole brains; however, whole-brain functional …

A platform for brain-wide volumetric functional ultrasound imaging and analysis of circuit dynamics in awake mice

C Brunner, M Grillet, A Sans-Dublanc, K Farrow… - Neuron, 2020 - cell.com
Imaging large-scale circuit dynamics is crucial to understanding brain function, but most
techniques have a limited depth of field. Here, we describe volumetric functional ultrasound …

[HTML][HTML] Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice

V Hingot, C Brodin, F Lebrun, B Heiles, A Chagnot… - Theranostics, 2020 - ncbi.nlm.nih.gov
In the field of ischemic cerebral injury, precise characterization of neurovascular
hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted …

Multiscale imaging informs translational mouse modeling of neurological disease

Y Wang, JM LeDue, TH Murphy - Neuron, 2022 - cell.com
Multiscale neurophysiology reveals that simple motor actions are associated with changes
in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal …

Quantitative hemodynamic measurements in cortical vessels using functional ultrasound imaging

C Brunner, E Macé, G Montaldo, A Urban - Frontiers in Neuroscience, 2022 - frontiersin.org
Red blood cell velocity (RBCv), cerebral blood flow (CBF), and volume (CBV) are three key
parameters when describing brain hemodynamics. Functional ultrasound imaging is a …

Functional ultrasound imaging of stroke in awake rats

C Brunner, G Montaldo, A Urban - Elife, 2023 - elifesciences.org
Anesthesia is a major confounding factor in preclinical stroke research as stroke rarely
occurs in sedated patients. Moreover, anesthesia affects both brain functions and the stroke …

[HTML][HTML] Functional ultrasound imaging: A useful tool for functional connectomics?

JMM de Paz, E Macé - NeuroImage, 2021 - Elsevier
Functional ultrasound (fUS) is a hemodynamic-based functional neuroimaging technique,
primarily used in animal models, that combines a high spatiotemporal resolution, a large …

Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke

C Brunner, NL Denis, K Gertz, M Grillet… - Journal of Cerebral …, 2024 - journals.sagepub.com
Ischemic stroke occurs abruptly causing sudden neurologic deficits, and therefore, very little
is known about hemodynamic perturbations in the brain immediately after stroke onset …