Serum autoantibodies as biomarkers for early cancer detection

HT Tan, J Low, SG Lim, MCM Chung - The FEBS journal, 2009 - Wiley Online Library
Autoantibodies against autologus tumor‐associated antigens have been detected in the
asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis …

Serologic autoantibodies as diagnostic cancer biomarkers—a review

P Zaenker, MR Ziman - Cancer Epidemiology, Biomarkers & Prevention, 2013 - AACR
Current diagnostic techniques used for the early detection of cancers are successful but
subject to detection bias. A recent focus lies in the development of more accurate diagnostic …

Seromic profiling of ovarian and pancreatic cancer

S Gnjatic, E Ritter, MW Büchler… - Proceedings of the …, 2010 - National Acad Sciences
Autoantibodies, a hallmark of both autoimmunity and cancer, represent an easily accessible
surrogate for measuring adaptive immune responses to cancer. Sera can now be assayed …

Biomarker discovery and clinical proteomics

J Silberring, P Ciborowski - TrAC Trends in Analytical Chemistry, 2010 - Elsevier
New biomarkers are urgently needed to accelerate efforts in developing new drugs and
treatments of known diseases. New clinical and translational proteomics studies emerge …

Autoantibodies-enemies, and/or potential allies?

H Ma, C Murphy, CE Loscher… - Frontiers in Immunology, 2022 - frontiersin.org
Autoantibodies are well known as potentially highly harmful antibodies which attack the host
via binding to self-antigens, thus causing severe associated diseases and symptoms (eg …

[HTML][HTML] Blood-based biomarkers for early detection of esophageal squamous cell carcinoma

LY Chu, YH Peng, XF Weng, JJ Xie… - World journal of …, 2020 - ncbi.nlm.nih.gov
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor of the
digestive system worldwide, especially in China. Due to the lack of effective early detection …

Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays

S Hu, A Vissink, M Arellano, C Roozendaal… - …, 2011 - Wiley Online Library
Sjögren's syndrome (SS) is a chronic, progressive autoimmune disease primarily affecting
women. Diagnosis of SS requires an invasive salivary gland tissue biopsy and a long delay …

[HTML][HTML] Tumor-associated autoantibodies as diagnostic and prognostic biomarkers

CK Heo, YY Bahk, EW Cho - BMB reports, 2012 - ncbi.nlm.nih.gov
In the process of tumorigenesis, normal cells are remodeled to cancer cells and protein
expression patterns are changed to those of tumor cells. A newly formed tumor …

A trial of intrapleural adenoviral-mediated Interferon-α2b gene transfer for malignant pleural mesothelioma

DH Sterman, A Haas, E Moon, A Recio… - American journal of …, 2011 - atsjournals.org
New therapeutic strategies are needed for malignant pleural mesothelioma (MPM). We
conducted a single-center, open-label, nonrandomized, pilot and feasibility trial using two …

IgM and IgA augmented autoantibody signatures improve early‐stage detection of colorectal cancer prior to nodal and distant spread

MSI Roney, C Lanagan, YH Sheng… - Clinical & …, 2021 - Wiley Online Library
Abstract Objectives Tumor‐associated autoantibodies (AAbs) in individuals with cancer can
precede clinical diagnosis by several months to years. The objective of this study was to …