Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Background The abundance of energy metabolites is intimately interconnected with the
activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of …

Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …

Recent research has unveiled an expansive role of NAD+ in cellular energy generation,
redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health …

Heterocyclic compounds are among the most prestigious and valuable chemical molecules
with diverse and magnificent applications in various sciences. Due to the remarkable and …

Dietary vitamin B3 components, such as nicotinamide and nicotinic acid, are precursors to
the ubiquitous redox cofactor nicotinamide adenine dinucleotide (NAD+). NAD+ levels are …

Gastrointestinal (GI) neoplasms include esophageal, gastric, colorectal, hepatic, and
pancreatic cancers. They are characterized by asymptomatic behavior, being responsible for …

Many studies have been written on vitamin supplementation, fatty acid, and dementia, but
results are still under debate, and no definite conclusion has yet been drawn. Nevertheless …

Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of
nicotinamide, using S-adenosyl-L-methionine as the methyl donor. Enzyme overexpression …

Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common disease in
Western countries and has become the major cause of liver cirrhosis or hepatocellular …