Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

INTRODUCTION Nucleosomes—the primary, repeating unit of chromatin—package and
protect the genome while also transmitting various regulatory signals through, in part …

DOT1 (disruptor of telomeric silencing; also called Kmt4) was initially discovered in budding
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …

The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …

The protein methyltransferases (PMTs)—which methylate protein lysine and arginine
residues and have crucial roles in gene transcription—are emerging as an important group …

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …

The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates
chromatin organization and either activates or represses gene expression, depending on …

Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …

The eukaryotic DNA is wrapped around histone octamers, which consist of four different
histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is post-transcriptionally …