Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

The success of targeted therapies and immunotherapies has created optimism that cancers
may be curable. However, not all patients respond, drug resistance is common and many …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …