This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

Sažetak Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents
(NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter …

Six chlorinated bispyridinium mono-oximes, analogous to potent charged reactivators K027,
K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p …

At the present, only four antidotes are in use in therapy for poisoning by organophosphorus
compounds: 2-PAM, HI-6, obidoxime and trimedoxime. Numerous compounds have been …

Organophosphorus (OP) compounds are highly toxic synthetic compounds which have been
used as pesticides and developed as warfare nerve agents. They represent a threat to both …

A library of 14 mono-oxime quinuclidinium-based compounds with alkyl or benzyl
substituent were synthesized and characterized in vitro as potential antidotes for …

The fluorinated bis-pyridinium oximes were designed and synthesized with the aim of
increasing their nucleophilicity and potential to reactivate phosphorylated human …

Molybdenum carbide (Mo 2 C) doping nitrogen nanoparticles (Mo 2 C/NCS) were
synthesized by a facile and friendly method. Owing to the high surface area and structural …

Organophosphorus (OP) compounds, including nerve agents and some pesticides,
covalently bind to the catalytic serine of human acetylcholinesterase (hAChE), thereby …

Background Thyroid cancer has been increasingly prevalent in recent years. The main
diagnostic methods for thyroid are B-ultrasound scan, serum detection and puncture …