Streptomyces bacteria are the major source of antibiotics and other secondary metabolites.
Various environmental and physiological conditions affect the onset and level of production …

Polyketides are a large group of secondary metabolites that have notable variety in their
structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial …

Polyketide natural products constitute a broad class of compounds with diverse structural
features and biological activities. Their biosynthetic machinery, represented by type I …

Corynebacterium glutamicum is a promising host for production of valuable polyketides.
Propionate addition, a strategy known to increase polyketide production by increasing …

Bacteria communicate via small diffusible molecules and thereby mediate group-
coordinated behavior, a process referred to as quorum sensing. The prototypical quorum …

Streptomyces, and related genera of Actinobacteria, are renowned for their ability to produce
antibiotics and other bioactive natural products with a wide range of applications in medicine …

Spore awakening is a series of actions that starts with purely physical processes and
continues via the launching of gene expression and metabolic activities, eventually …

Microorganisms produce numerous secondary metabolites (SMs) with various biological
activities. Many of their encoding gene clusters are silent under standard laboratory …

Polyketides are structurally and functionally diverse secondary metabolites that are
biosynthesized by polyketide synthases (PKSs) using acyl-CoA precursors. Recent studies …

Covering: up to 2014 The modular polyketide synthases (PKSs) are multienzyme proteins
responsible for the assembly of diverse secondary metabolites of high economic and …